Masafumi Matsuo Selected Research

Wasting Syndrome (Wasting Disease)

1/2022	A sandwich ELISA kit reveals marked elevation of titin N-terminal fragment levels in the urine of mdx mice.
9/2021	Renadirsen, a Novel 2'OMeRNA/ENA® Chimera Antisense Oligonucleotide, Induces Robust Exon 45 Skipping for Dystrophin In Vivo.
9/2021	Dystrophin Dp71 Subisoforms Localize to the Mitochondria of Human Cells.
7/2021	Antisense Oligonucleotide-Mediated Exon-skipping Therapies: Precision Medicine Spreading from Duchenne Muscular Dystrophy.
2/2017	2'-O-Methyl RNA/Ethylene-Bridged Nucleic Acid Chimera Antisense Oligonucleotides to Induce Dystrophin Exon 45 Skipping.
1/2017	DMD transcripts in CRL-2061 rhabdomyosarcoma cells show high levels of intron retention by intron-specific PCR amplification.
4/2016	Next-generation sequencing discloses a nonsense mutation in the dystrophin gene from long preserved dried umbilical cord and low-level somatic mosaicism in the proband mother.
9/2015	Neuronal SH-SY5Y cells use the C-dystrophin promoter coupled with exon 78 skipping and display multiple patterns of alternative splicing including two intronic insertion events.
8/2013	A prostaglandin D2 metabolite is elevated in the urine of Duchenne muscular dystrophy patients and increases further from 8 years old.
3/2012	Categorization of 77 dystrophin exons into 5 groups by a decision tree using indexes of splicing regulatory factors as decision markers.

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Masafumi Matsuo Research Topics

Disease

67	Duchenne Muscular Dystrophy (Muscular Dystrophy, Becker) 01/2022 - 01/2002
14	Neoplasms (Cancer) 01/2017 - 09/2002
13	Wasting Syndrome (Wasting Disease) 01/2022 - 05/2006
9	Muscular Dystrophies (Muscular Dystrophy) 01/2020 - 12/2006
6	Hereditary Nephritis (Alport Syndrome) 01/2022 - 12/2006
5	Intellectual Disability (Idiocy) 09/2016 - 09/2002
5	Glucosephosphate Dehydrogenase Deficiency 06/2005 - 08/2002
4	Insulin Resistance 08/2015 - 02/2003
4	Neuroblastoma 03/2015 - 07/2011
3	Gitelman Syndrome 09/2022 - 04/2007
3	Hepatocellular Carcinoma (Hepatoma) 08/2021 - 02/2003
3	Body Weight (Weight, Body) 10/2020 - 08/2004
3	Glioblastoma (Glioblastoma Multiforme) 05/2020 - 01/2019
3	Colorectal Neoplasms (Colorectal Cancer) 03/2015 - 02/2003
3	Sepsis (Septicemia) 12/2014 - 06/2009
3	Gilbert Disease 12/2012 - 08/2002
3	Neoplasm Metastasis (Metastasis) 12/2007 - 12/2004
3	Proteinuria 12/2006 - 11/2005
3	Neonatal Jaundice 06/2005 - 08/2002
3	Adenocarcinoma 12/2004 - 01/2002
3	Malaria 01/2003 - 01/2003
2	Rhabdomyosarcoma 04/2022 - 05/2018
2	Walker-Warburg Syndrome 10/2021 - 01/2021
2	Critical Illness (Critically Ill) 02/2021 - 01/2020
2	Muscular Atrophy (Muscle Atrophy) 02/2021 - 01/2020
2	Muscular Diseases (Myopathy) 01/2018 - 01/2017
2	Hypercalciuria 12/2017 - 08/2007
2	Inborn Genetic Diseases (Disease, Hereditary) 12/2017 - 10/2003
2	Acidosis 12/2017 - 11/2009
2	Nephrocalcinosis 12/2017 - 08/2007
2	Lymphoma (Lymphomas) 03/2015 - 01/2007
2	Lymphoproliferative Disorders (Lymphoproliferative Disorder) 12/2014 - 11/2005
2	Tuberous Sclerosis (Bourneville's Disease) 06/2011 - 05/2008
2	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 10/2010 - 01/2007
2	Breast Neoplasms (Breast Cancer) 08/2010 - 01/2007
2	Bartter Syndrome (Syndrome, Bartter) 10/2009 - 09/2007
2	Spinal Muscular Atrophy (Progressive Muscular Atrophy) 03/2009 - 02/2007
2	Maple Syrup Urine Disease 06/2008 - 02/2004
2	Hemolytic-Uremic Syndrome 04/2007 - 08/2004
2	Nephrotic Syndrome (Syndrome, Nephrotic) 11/2005 - 07/2005
2	Hemolysis 06/2005 - 03/2005
2	Jaundice (Icterus) 06/2005 - 08/2002
1	Birth Weight (Birth Weights) 01/2022
1	Diamond-Blackfan Anemia (Anemia, Diamond Blackfan) 09/2021
1	Rare Diseases (Rare Disease) 07/2021

Drug/Important Bio-Agent (IBA)

56	DystrophinIBA 01/2022 - 01/2002
17	Messenger RNA (mRNA)IBA 01/2022 - 01/2002
16	Proteins (Proteins, Gene)FDA Link 10/2021 - 02/2003
10	Antisense OligonucleotidesIBA 09/2021 - 08/2004
9	Protein Isoforms (Isoforms)IBA 01/2022 - 07/2011
9	ConnectinIBA 01/2022 - 12/2016
9	Nonsense Codon (Nonsense Mutation)IBA 09/2021 - 03/2004
5	Biomarkers (Surrogate Marker)IBA 02/2021 - 06/2012
5	DNA (Deoxyribonucleic Acid)IBA 12/2014 - 01/2002
4	RNA Precursors (Precursor, mRNA)IBA 09/2021 - 10/2011
4	Pharmaceutical PreparationsIBA 10/2020 - 03/2004
4	Complementary DNA (cDNA)IBA 05/2020 - 05/2004
3	SaltsIBA 09/2022 - 10/2009
3	MyostatinIBA 04/2022 - 04/2007
3	EnzymesIBA 01/2019 - 06/2008
3	RNA (Ribonucleic Acid)IBA 03/2015 - 08/2004
3	Methylenetetrahydrofolate Reductase (NADPH2) (Methylenetetrahydrofolate Reductase)IBA 08/2010 - 12/2002
3	Oxidoreductases (Dehydrogenase)IBA 06/2008 - 08/2004
3	Glucosephosphate Dehydrogenase (Glucose 6 Phosphate Dehydrogenase)IBA 02/2003 - 01/2003
2	ChloridesIBA 09/2022 - 12/2010
2	Insulin ReceptorIBA 08/2021 - 08/2015
2	Uric Acid (Urate)IBA 01/2020 - 12/2009
2	dirhodium tetraacetate (DRTA)IBA 12/2017 - 01/2003
2	Small Interfering RNA (siRNA)IBA 03/2015 - 02/2013
2	Rituximab (Mabthera)FDA Link 12/2014 - 11/2005
2	Creatine Kinase (Creatine Phosphokinase)IBA 06/2012 - 10/2010
2	Monomeric GTP-Binding ProteinsIBA 06/2012 - 07/2011
2	trans-sodium crocetinate (crocetin)IBA 06/2011 - 05/2008
2	SteroidsIBA 04/2011 - 02/2006
2	BilirubinIBA 01/2011 - 08/2002
2	Collagen Type IV (Type IV Collagen)IBA 10/2010 - 08/2008
2	Glutathione Transferase (Glutathione S-Transferase)IBA 08/2010 - 01/2007
2	Reduced Folate Carrier ProteinIBA 08/2010 - 01/2007
2	Codon (Codons)IBA 03/2010 - 10/2004
2	Glucose (Dextrose)FDA LinkGeneric 12/2009 - 06/2005
2	AldosteroneIBA 11/2009 - 12/2006
2	Immunoglobulin E (IgE)IBA 06/2009 - 01/2005
2	Testosterone (Sustanon)FDA Link 06/2009 - 01/2007
2	GonadotropinsIBA 06/2009 - 01/2007
2	Cyclosporine (Ciclosporin)FDA LinkGeneric 12/2007 - 07/2005
2	NucleotidesIBA 04/2007 - 01/2002
2	Uridine Diphosphate (UDP)IBA 01/2006 - 08/2002
2	Glucuronosyltransferase (UDP Glucuronosyltransferase)IBA 01/2006 - 08/2002
2	Anti-Bacterial Agents (Antibiotics)IBA 09/2005 - 04/2004
2	AminoglycosidesIBA 09/2005 - 04/2004
2	Multidrug Resistance-Associated ProteinsIBA 03/2004 - 01/2002
2	multidrug resistance-associated protein 1IBA 03/2004 - 01/2002
2	Fluorouracil (Carac)FDA LinkGeneric 10/2003 - 09/2002
2	Cytochrome P-450 CYP3AIBA 02/2003 - 01/2002
1	Dystroglycans (Dystroglycan)IBA 10/2021
1	Ribosomal Proteins (Ribosomal Protein)IBA 09/2021

Therapy/Procedure

16	Therapeutics 07/2021 - 03/2002
4	Drug Therapy (Chemotherapy) 03/2015 - 09/2002
4	Ligation 06/2013 - 01/2004
1	Precision Medicine 07/2021